• br Funding Source This study

  2018-11-07

  

  Funding Source This study was funded by Mesoblast, Inc. Contributors Declaration of Interests Prior Presentation Acknowledgements Introduction In 1933, Henrik Sjögren, in his doctoral dissertation introduced the neologism, keratoconjunctivitis Sicca (Murube, 2010, Sjögren, 1933).

• To determine if the overexpression of miR

  2018-11-07

  

  To determine if the overexpression of miR-137 negatively regulate EFNB2 expression, human neuroblastoma SH-SY5Y cells were transfected with mature miR-137 sequences or negative control miRNAs. The results showed that the overexpression of miR-137 did not affect the mRNA expression of EFNB2 but signi

• In a more than five year

  2018-11-07

  

  In a more than five-year-long study, we used a non-isogenic respiratory chain (RC) deficient mouse strain, namely the Harlequin (Hq) mouse, to test a set of drugs. We previously attributed the Hq mouse phenotype to a partial defect of RC complex I (CI) activity (Vahsen et al., 2004), due to a retrov

• For various cancer types HDAC acts as an

  2018-11-07

  

  For various cancer types, HDAC2 acts as an oncogene through the epigenetic regulation of genes and the corresponding signaling cascades in cancer development, and HDAC2 expression is gradually increases, from pre-neoplastic lesions, to low-grade dysplastic nodules, high-grade dysplastic nodules, and

• The decrease in blood oxygen saturation correlates with incr

  2018-11-07

  

  The decrease in blood oxygen saturation correlates with increased plasma EPO levels in Slc40a1C326S/C326S mice. Hypoxia is the main physiological inducer of EPO production in the kidney via the hypoxia inducible factor HIF2α/HIF1β heterodimer (Haase, 2010). In Slc40a1C326S/C326S mice iron may also d

• Differences in aluminum concentration between

  2018-11-07

  

  Differences in aluminum concentration between cases and controls were only evident when restricting the analysis to cases with tumors in the upper outer quadrant, supporting the hypothesis of Darbre (2005, Darbre, 2009) that tumors in the upper outer quadrant are affected by the use of UCPs. Results

• In the frame of a larger study

  2018-11-07

  

  In the frame of a larger study we investigated as well tree parameters, these were coded as eight environmental variables. Vitality of the trees (vit), was assessed using a five-divided scale: 1=all branches green, ending with freshly grown shoots; 2=5–15% dead branches, crown intact, fresh growth i

• br Experimental design materials and methods br Acknowledgem

  2018-11-07

  

  Experimental design, materials and methods Acknowledgements This research was supported by the Knut & Alice Wallenberg Foundation via the Wallenberg Wood Science Center, the Swedish Research Council Formas via CarboMat, and the European Research Council through Grant 336355 (“MicroDE”). The au

• br Experimental design materials and methods br Acknowledgem

  2018-11-07

  

  Experimental design, materials and methods Acknowledgements This research was supported by the Knut & Alice Wallenberg Foundation via the Wallenberg Wood Science Center, the Swedish Research Council Formas via CarboMat, and the European Research Council through Grant 336355 (“MicroDE”). The au

• sphingosine kinase inhibitor In psychology previous studies

  2018-11-07

  

  In psychology, previous studies have categorized individual cognitive patterns using factor index scores in typically developing children (Donders, 1996; Glutting et al., 1994), as well as in clinically referred children or children with neurodevelopmental disorders, such as autism, traumatic sphing

• However an accumulation of evidence later

  2018-11-07

  

  However, an accumulation of evidence later indicated that vulnerable individuals identified in diathesis–stress models might instead be viewed as sensitive, developmentally plastic, and malleable vis-à-vis environmental influences, regardless of their valence. This alternate perspective led to the b

• We used a mixed model ANOVA to evaluate whether the

  2018-11-07

  

  We used a mixed-model ANOVA to evaluate whether the ERPs of the selective attention effect varied as a function of 5-HTTLPR. The ANOVA included the between-group factor of three 5-HTTLPR genotypes (long-long, short-long, and short-short), and the within-group factor of three levels of electrode loca

• br Theory and hypotheses br Methodology br

  2018-11-06

  

  Theory and hypotheses Methodology Data analysis Table 1 provides means, standard deviations and bivariate correlations of all the variables. The correlations coefficients provide initial support for our study hypotheses. Consistent with our hypotheses, the bivariate correlations indicate th

• Since the s there have been continuous empirical

  2018-11-06

  

  Since the 1970s there have been continuous empirical studies in western countries indicating that chir99021 natural environments have therapeutic effects. For instance, Olds (1985) examines the therapeutic effects of nature by interviewing focus groups in a coherent workshop for several years, and c

• In this study the patient presented with normal functions of

  2018-11-06

  

  In this study, the patient presented with normal functions of the trapezius and sternocleidomastoid muscles. Why did the accessory nerve remain intact when cranial nerves IX and X were affected? The spinal root of the accessory nerve may be less vulnerable than the glossopharyngeal and vagus nerves

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